ExplorEnz: EC 5.6.1.1

Your query returned 1 entry. Printable version

5.6.1.1

Accepted name:

microtubule-severing ATPase

Reaction:

n ATP + n H₂O + a microtubule = n ADP + n phosphate + (n+1) α/β tubulin heterodimers

Other name(s):

katanin

Systematic name:

ATP phosphohydrolase (tubulin-dimerizing)

Comments:

A member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	McNally, F.J. and Vale, R.D. Identification of katanin, an ATPase that severs and disassembles stable microtubules. Cell 75 (1993) 419–429. [DOI] [PMID: 8221885]
2.	Hartman, J.J., Mahr, J., McNally, K., Okawa, K., Iwamatsu, A., Thomas, S., Cheesman, S., Heuser, J., Vale, R.D. and McNally, F.J. Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell 93 (1998) 277–287. [DOI] [PMID: 9568719]

[EC 5.6.1.1 created 2000 as 3.6.4.3, transferred 2018 to EC 5.6.1.1]