ExplorEnz: EC 5.4.1.3

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5.4.1.3

Accepted name:

2-methylfumaryl-CoA isomerase

Reaction:

2-methylfumaryl-CoA = 3-methylfumaryl-CoA

For diagram of the 3-hydroxypropanoate cycle, click here

Glossary:

2-methylfumaryl-CoA = (E)-3-carboxy-2-methylprop-2-enoyl-CoA
3-methylfumaryl-CoA = (E)-3-carboxybut-2-enoyl-CoA

Other name(s):

mesaconyl-CoA C₁-C₄ CoA transferase; Mct

Systematic name:

2-methylfumaryl-CoA 1,4-CoA-mutase

Comments:

The enzyme, purified from the bacterium Chloroflexus aurantiacus, acts as an intramolecular CoA transferase and does not transfer CoA to free mesaconate. It is part of the 3-hydroxypropanoate cycle for carbon assimilation.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Zarzycki, J., Brecht, V., Muller, M. and Fuchs, G. Identifying the missing steps of the autotrophic 3-hydroxypropionate CO₂ fixation cycle in Chloroflexus aurantiacus. Proc. Natl. Acad. Sci. USA 106 (2009) 21317–21322. [DOI] [PMID: 19955419]

[EC 5.4.1.3 created 2014]