| EC |
5.3.99.5 |
| Accepted name: |
thromboxane-A synthase |
| Reaction: |
(5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9α,11α-epoxy-15-hydroxythromboxa-5,13-dienoate |
| Other name(s): |
thromboxane synthase; (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase |
| Systematic name: |
(5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase |
| Comments: |
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 61276-89-9 |
| References: |
| 1. |
Shen, R.-F. and Tai, H.-H. Immunoaffinity purification and characterization of thromboxane synthase from porcine lung. J. Biol. Chem. 261 (1986) 11592–11599. [PMID: 3745158] |
| 2. |
Ullrich, V. and Haurand, M. Thromboxane synthase as a cytochrome P450 enzyme. Adv. Prostaglandin Thromboxane Res. 11 (1983) 105–110. [PMID: 6221511] |
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| [EC 5.3.99.5 created 1984, modified 1990] |
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