ExplorEnz: EC 5.1.99.7

Your query returned 1 entry. Printable version

5.1.99.7

Accepted name:

dihydroneopterin triphosphate 2′-epimerase

Reaction:

7,8-dihydroneopterin 3′-triphosphate = 7,8-dihydromonapterin 3′-triphosphate

For diagram of monapterin biosynthesis, click here

Glossary:

7,8-dihydroneopterin 3′-triphosphate = (2R,3S)-3-(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)-2,3-dihydroxypropyl triphosphate
7,8-dihydromonapterin 3′-triphosphate = (2S,3S)-3-(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)-2,3-dihydroxypropyl triphosphate

Other name(s):

D-erythro-7,8-dihydroneopterin triphosphate epimerase; folX (gene name)

Systematic name:

7,8-dihydroneopterin 3′-triphosphate 2′-epimerase

Comments:

The enzyme, found in gammaproteobacteria, has almost no activity with 7,8-dihydroneopterin [2].

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Ahn, C., Byun, J. and Yim, J. Purification, cloning, and functional expression of dihydroneopterin triphosphate 2′-epimerase from Escherichia coli. J. Biol. Chem. 272 (1997) 15323–15328. [DOI] [PMID: 9182560]
2.	Haussmann, C., Rohdich, F., Schmidt, E., Bacher, A. and Richter, G. Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase. J. Biol. Chem. 273 (1998) 17418–17424. [DOI] [PMID: 9651328]

[EC 5.1.99.7 created 2015]