The Enzyme Database

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EC 5.1.1.24     
Accepted name: histidine racemase
Reaction: L-histidine = D-histidine
For diagram of staphylopine biosynthesis, click here
Glossary: staphylopine = (2S)-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}-2-[(1-carboxyethyl)amino]butanoate
Other name(s): cntK (gene name)
Systematic name: histidine racemase
Comments: The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Ghssein, G., Brutesco, C., Ouerdane, L., Fojcik, C., Izaute, A., Wang, S., Hajjar, C., Lobinski, R., Lemaire, D., Richaud, P., Voulhoux, R., Espaillat, A., Cava, F., Pignol, D., Borezee-Durant, E. and Arnoux, P. Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus. Science 352 (2016) 1105–1109. [PMID: 27230378]
[EC 5.1.1.24 created 2019]
 
 


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