| EC |
4.6.1.1 |
| Accepted name: |
adenylate cyclase |
| Reaction: |
ATP = 3′,5′-cyclic AMP + diphosphate |
| Other name(s): |
adenylylcyclase; adenyl cyclase; 3′,5′-cyclic AMP synthetase; ATP diphosphate-lyase (cyclizing) |
| Systematic name: |
ATP diphosphate-lyase (cyclizing; 3′,5′-cyclic-AMP-forming) |
| Comments: |
Also acts on dATP to form 3′,5′-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+—arginine ADP-ribosyltransferase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9012-42-4 |
| References: |
| 1. |
Hirata, M. and Hayaishi, O. Adenyl cyclase of Brevibacterium liquefaciens. Biochim. Biophys Acta 149 (1967) 1–11. [DOI] [PMID: 4295782] |
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| [EC 4.6.1.1 created 1972] |
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