EC |
4.4.1.5 |
Accepted name: |
lactoylglutathione lyase |
Reaction: |
(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
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Glossary: |
2-oxopropanal = methylglyoxal |
Other name(s): |
methylglyoxalase; aldoketomutase; ketone-aldehyde mutase; glyoxylase I; (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) |
Systematic name: |
(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming) |
Comments: |
Also acts on 3-phosphoglycerol-glutathione. |
Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9033-12-9 |
References: |
1. |
Ekwall, K. and Mannervik, B. The stereochemical configuration of the lactoyl group of S-lactoylglutathionine formed by the action of glyoxalase I from porcine erythrocytes and yeast. Biochim. Biophys. Acta 297 (1973) 297–299. [DOI] [PMID: 4574550] |
2. |
Racker, E. The mechanism of action of glyoxalase. J. Biol. Chem. 190 (1951) 685–696. [PMID: 14841219] |
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[EC 4.4.1.5 created 1961] |
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