ExplorEnz: EC 4.2.99.24

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4.2.99.24

Accepted name:

thebaine synthase

Reaction:

salutaridinol 7-O-acetate = thebaine + acetate

For diagram of thebaine biosynthesis, click here

Other name(s):

THS

Systematic name:

salutaridinol 7-O-acetate acetate-lyase (thebaine-forming)

Comments:

Isolated from the plant Papaver somniferum (opium poppy). The reaction occurs spontaneously when the pH is between 8-9, but the enzyme is required at the physiological pH, which is close to 7.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

Chen, X., Hagel, J.M., Chang, L., Tucker, J.E., Shiigi, S.A., Yelpaala, Y., Chen, H.Y., Estrada, R., Colbeck, J., Enquist-Newman, M., Ibanez, A.B., Cottarel, G., Vidanes, G.M. and Facchini, P.J. A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis. Nat. Chem. Biol. 14 (2018) 738–743. [PMID: 29807982]

[EC 4.2.99.24 created 2019]