The Enzyme Database

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Accepted name: presilphiperfolanol synthase
Reaction: (2E,6E)-farnesyl diphosphate + H2O = presilphiperfolan-8β-ol + diphosphate
For diagram of bicyclic and tricyclic sesquiterpenoids derived from humuladienyl cation, click here and for diagram of mechanism, click here
Other name(s): BcBOT2; CND15
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphohydrolase (presilphiperfolan-8β-ol-forming)
Comments: Requires Mg2+. Presilphiperfolan-8β-ol is the precursor of botrydial, a phytotoxic sesquiterpene metabolite secreted by the fungus Botryotinia fuckeliana (Botrytis cinerea), the causal agent of gray mold disease in plants.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Pinedo, C., Wang, C.M., Pradier, J.M., Dalmais, B., Choquer, M., Le Pecheur, P., Morgant, G., Collado, I.G., Cane, D.E. and Viaud, M. Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea. ACS Chem. Biol. 3 (2008) 791–801. [DOI] [PMID: 19035644]
2.  Wang, C.M., Hopson, R., Lin, X. and Cane, D.E. Biosynthesis of the sesquiterpene botrydial in Botrytis cinerea. Mechanism and stereochemistry of the enzymatic formation of presilphiperfolan-8β-ol. J. Am. Chem. Soc. 131 (2009) 8360–8361. [DOI] [PMID: 19476353]
[EC created 2011]

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