| EC |
4.2.3.157 |
| Accepted name: |
(+)-isoafricanol synthase |
| Reaction: |
(2E,6E)-farnesyl diphosphate + H2O = (+)-isoafricanol + diphosphate |
| Glossary: |
(+)-isoafricanol = (1aS,4aR,5R,7aS,7bR)-3,3,5,7b-tetramethyldecahydro-4aH-cyclopropa[e]azulen-4a-ol |
| Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-isoafricanol-forming] |
| Comments: |
(+)-Isoafricanol is a sesquiterpene alcohol. Its synthesis has been shown to occur in the bacteria Streptomyces violaceusniger and Streptomyces malaysiensis. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Riclea, R., Citron, C.A., Rinkel, J. and Dickschat, J.S. Identification of isoafricanol and its terpene cyclase in Streptomyces violaceusniger using CLSA-NMR. Chem. Commun. (Camb.) 50 (2014) 4228–4230. [DOI] [PMID: 24626486] |
| 2. |
Rabe, P., Samborskyy, M., Leadlay, P.F. and Dickschat, J.S. Isoafricanol synthase from Streptomyces malaysiensis. Org. Biomol. Chem. 15 (2017) 2353–2358. [DOI] [PMID: 28247907] |
|
| [EC 4.2.3.157 created 2017] |
| |
|
| |
|
Printable version