ExplorEnz: EC 4.2.3.141

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4.2.3.141

Accepted name:

sclareol synthase

Reaction:

(13E)-8α-hydroxylabd-13-en-15-yl diphosphate + H₂O = sclareol + diphosphate

For diagram of hydroxylabdenyl diphosphate derived diterpenoids, click here

Glossary:

sclareol = (13R)-labd-14-ene-8α,13-diol
(13E)-8α-hydroxylabd-13-en-15-yl diphosphate = 8-hydroxycopalyl diphosphate

Other name(s):

Systematic name:

(13E)-8α-hydroxylabd-13-en-15-yl-diphosphate-lyase (sclareol-forming)

Comments:

Isolated from the plant Salvia sclarea (clary sage). Originally thought to be synthesized in one step from geranylgeranyl diphosphate it is now known to require two enzymes, EC 4.2.1.133, copal-8-ol diphosphate synthase and EC 4.2.3.141, sclareol synthase. Sclareol is used in perfumery.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Caniard, A., Zerbe, P., Legrand, S., Cohade, A., Valot, N., Magnard, J.L., Bohlmann, J. and Legendre, L. Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture. BMC Plant Biol. 12:119 (2012). [DOI] [PMID: 22834731]

[EC 4.2.3.141 created 2013, modified 2017]