| EC |
4.2.1.54 |
| Accepted name: |
lactoyl-CoA dehydratase |
| Reaction: |
(R)-lactoyl-CoA = acryloyl-CoA + H2O |
| Other name(s): |
lactoyl coenzyme A dehydratase; lactyl-coenzyme A dehydrase; lactyl CoA dehydratase; acrylyl coenzyme A hydratase; lactoyl-CoA hydro-lyase |
| Systematic name: |
(R)-lactoyl-CoA hydro-lyase (acryloyl-CoA-forming) |
| Comments: |
A bacterial enzyme that is involved in propanoate fermentation (also known as the acrylate pathway). |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, CAS registry number: 9031-12-3 |
| References: |
| 1. |
Baldwin, R.L., Wood, W.A. and Emery, R.S. Lactate metabolism by Peptostreptococcus elsdenii: evidence for lactyl coenzyme a dehydrase. Biochim. Biophys. Acta 97 (1965) 202–213. [DOI] [PMID: 14292829] |
| 2. |
Schweiger, G. and Buckel, W. On the dehydration of (R)-lactate in the fermentation of alanine to propionate by Clostridium propionicum. FEBS Lett. 171 (1984) 79–84. [DOI] [PMID: 6586495] |
| 3. |
Kuchta, R.D. and Abeles, R.H. Lactate reduction in Clostridium propionicum. Purification and properties of lactyl-CoA dehydratase. J. Biol. Chem. 260 (1985) 13181–13189. [PMID: 4055736] |
| 4. |
Kuchta, R.D., Hanson, G.R., Holmquist, B. and Abeles, R.H. Fe-S centers in lactyl-CoA dehydratase. Biochemistry 25 (1986) 7301–7307. [PMID: 3026450] |
| 5. |
Hofmeister, A.E. and Buckel, W. (R)-Lactyl-CoA dehydratase from Clostridium propionicum. Stereochemistry of the dehydration of (R)-2-hydroxybutyryl-CoA to crotonyl-CoA. Eur. J. Biochem. 206 (1992) 547–552. [DOI] [PMID: 1597194] |
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| [EC 4.2.1.54 created 1972, modified 2012] |
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