ExplorEnz: EC 4.2.1.105

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4.2.1.105

Accepted name:

2-hydroxyisoflavanone dehydratase

Reaction:

(1) 2,4′,7-trihydroxyisoflavanone = daidzein + H₂O
(2) 2,4′,5,7-tetrahydroxyisoflavanone = genistein + H₂O

For diagram of biochanin A biosynthesis, click here and for diagram of daidzein biosynthesis, click here

Glossary:

daidzein = 4′,7-dihydroxyisoflavone
genistein = 4′,5,7-dihydroxyisoflavone

Other name(s):

2,7,4′-trihydroxyisoflavanone hydro-lyase; 2,7,4′-trihydroxyisoflavanone hydro-lyase (daidzein-forming)

Systematic name:

2,4′,7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)

Comments:

Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 166800-10-8

References:

1.	Hakamatsuka, T., Mori, K., Ishida, S., Ebizuka, Y and Sankawa, U. Purification of 2-hydroxyisoflavanone dehydratase from the cell cultures of Pueraria lobata. Phytochemistry 49 (1998) 497–505.

[EC 4.2.1.105 created 2004, modified 2013]