ExplorEnz: EC 4.1.2.50

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4.1.2.50

Accepted name:

6-carboxytetrahydropterin synthase

Reaction:

7,8-dihydroneopterin 3′-triphosphate + H₂O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate

For diagram of queuine biosynthesis, click here

Glossary:

7,8-dihydroneopterin 3′-triphosphate = 2-amino-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-4-oxo-2,3,7,8-tetrahydropteridine
6-carboxy-5,6,7,8-tetrahydropterin = 2-amino-4-oxo-2,3,5,6,7,8-hexahydropteridine-6-carboxylate

Other name(s):

CPH4 synthase; queD (gene name); ToyB; ykvK (gene name)

Systematic name:

7,8-dihydroneopterin 3′-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming)

Comments:

Binds Zn²⁺. Isolated from the bacteria Bacillus subtilis and Escherichia coli. The reaction is part of the biosynthesis pathway of queuosine.The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8-tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-tetrahydropterin [2].

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Cicmil, N. and Shi, L. Crystallization and preliminary X-ray characterization of queD from Bacillus subtilis, an enzyme involved in queuosine biosynthesis. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 (2008) 119–122. [DOI] [PMID: 18259064]
2.	McCarty, R.M., Somogyi, A. and Bandarian, V. Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase. Biochemistry 48 (2009) 2301–2303. [DOI] [PMID: 19231875]

[EC 4.1.2.50 created 2012]