| EC |
3.6.5.2 |
| Accepted name: |
small monomeric GTPase |
| Reaction: |
GTP + H2O = GDP + phosphate |
| Systematic name: |
GTP phosphohydrolase (cell-regulating) |
| Comments: |
A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the α-subunit of heterotrimeric G-protein GTPase (EC 3.6.5.1). They are involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Bourne, H.R., Sanders, D.A. and McCormick, F. The GTPase superfamily: conserved structure and molecular mechanisms. Nature 349 (1991) 117–127. [DOI] [PMID: 1898771] |
| 2. |
Hall, A. Small GTP-binding proteins and the regulation of actin cytoskeleton. Annu. Rev. Cell Biol. 10 (1994) 31–54. [DOI] [PMID: 7888179] |
| 3. |
Geyer, M. and Wittinghofer, A. GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins. Curr. Opin. Struct. Biol. 7 (1997) 786–792. [DOI] [PMID: 9434896] |
| 4. |
Vitale, N., Moss, J. and Vaughan, M. Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1). J. Biol. Chem. 273 (1998) 2553–2560. [DOI] [PMID: 9446556] |
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| [EC 3.6.5.2 created 2000 as EC 3.6.1.47, transferred 2003 to EC 3.6.5.2] |
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