ExplorEnz: EC 3.5.3.27

Your query returned 1 entry. Printable version

3.5.3.27

Accepted name:

arginine dihydrolase

Reaction:

L-arginine + 2 H₂O = L-ornithine + CO₂ + 2 ammonia

Other name(s):

argZ (gene name)

Systematic name:

L-arginine aminodihydrolase (L-ornithine-forming)

Comments:

The enzyme, characterized from different cyanobacterial species, is highly specific to arginine and does not require a metal cofactor. The enzyme from Nostoc is bifunctional, and also catalyses the activity of EC 4.3.1.12, ornithine cyclodeaminase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Zhang, H., Liu, Y., Nie, X., Liu, L., Hua, Q., Zhao, G.P. and Yang, C. The cyanobacterial ornithine-ammonia cycle involves an arginine dihydrolase. Nat. Chem. Biol. 14 (2018) 575–581. [DOI] [PMID: 29632414]
2.	Burnat, M., Picossi, S., Valladares, A., Herrero, A. and Flores, E. Catabolic pathway of arginine in Anabaena involves a novel bifunctional enzyme that produces proline from arginine. Mol. Microbiol. 111 (2019) 883–897. [DOI] [PMID: 30636068]
3.	Zhuang, N., Zhang, H., Li, L., Wu, X., Yang, C. and Zhang, Y. Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism. J. Biol. Chem. 295 (2020) 2113–2124. [DOI] [PMID: 31914412]

[EC 3.5.3.27 created 2024]