| EC |
3.4.24.84 |
| Accepted name: |
Ste24 endopeptidase |
| Reaction: |
The peptide bond hydrolysed can be designated -C┼aaX in which C is an S-isoprenylated cysteine residue, a is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids |
| Comments: |
Type example of peptidase family M48. One of two enzymes that can catalyse this processing step for mating a-factor in yeast. Subsequently, the S-isoprenylated cysteine residue that forms the new C-terminus is methyl-esterified and forms a hydrophobic membrane-anchor. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 148463-92-7 |
| References: |
| 1. |
Tam, A., Schmidt, W.K. and Michaelis, S. The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor. J. Biol. Chem. 276 (2001) 46798–46806. [DOI] [PMID: 11581258] |
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| [EC 3.4.24.84 created 2003] |
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