| EC |
3.4.24.47 |
| Accepted name: |
horrilysin |
| Reaction: |
Cleavage of only the single bond Ala14┼Leu in the insulin B chain, Ser12┼Leu in the A chain, and Ile┼Gly, Pro┼Ala, and Ser┼Trp in melittin |
| Other name(s): |
Crotalus horridus metalloendopeptidase; hemorrhagic proteinase IV; Crotalus horridus horridus venom hemorrhagic proteinase |
| Comments: |
A 56 kDa hemorrhagic endopeptidase from the venom of the timber rattlesnake (Crotalus horridus horridus) that cleaves basement membrane, hide powder and fibrinogen. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 84056-81-5 |
| References: |
| 1. |
Civello, D.J., Duong, H.L. and Geren, C.R. Isolation and characterization of a hemorrhagic proteinase from timber rattlesnake venom. Biochemistry 22 (1983) 749–755. [PMID: 6340728] |
| 2. |
Civello, D.J., Moran, J.B. and Geren, C.R. Substrate specificity of a hemorrhagic proteinase from timber rattlesnake venom. Biochemistry 22 (1983) 755–762. [PMID: 6340729] |
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| [EC 3.4.24.47 created 1992] |
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