| EC |
3.4.24.13 |
| Accepted name: |
IgA-specific metalloendopeptidase |
| Reaction: |
Cleavage of Pro┼Thr bond in the hinge region of the heavy chain of human IgA |
| Other name(s): |
immunoglobulin A1 proteinase; IgA protease; IgA1-specific proteinase; IgA1 protease; IgA1 proteinase |
| Comments: |
A 190 kDa enzyme found in several pathogenic species of Streptococcus such as sanguis and pneumoniae. Type example of peptidase family M26. There is also an IgA-specific prolyl endopeptidase of the serine-type (see EC 3.4.21.72, IgA-specific serine endopeptidase) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 72231-73-3 |
| References: |
| 1. |
Kornfeld, S.J. and Plaut, A.G. Secretory immunity and the bacterial IgA proteases. Rev. Infect. Dis. 3 (1981) 521–534. [PMID: 6792682] |
| 2. |
Gilbert, J.V., Plaut, A.G. and Wright, A. Analysis of the immunoglobulin A protease gene of Streptococcus sanguis. Infect. Immun. 59 (1991) 7–17. [PMID: 1987065] |
| 3. |
Gilbert, J.V., Plaut, A.G., Fishman, Y. and Wright, A. Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli. Infect. Immun. 56 (1988) 1961–1966. [PMID: 3294181] |
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| [EC 3.4.24.13 created 1984] |
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