| EC |
3.4.23.4 |
| Accepted name: |
chymosin |
| Reaction: |
Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe105┼Met-Ala bond in κ-chain of casein |
| Other name(s): |
rennin (but this should be avoided since it leads to confusion with renin) |
| Comments: |
Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1(pepsin A family) |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9001-98-3 |
| References: |
| 1. |
Foltmann, B. A review of prorennin and rennin. C. R. Trav. Lab. Carlsberg 35 (1966) 143–231. [PMID: 5330666] |
| 2. |
Harris, T.J.R., Lowe, P.A., Lyons, A., Thomas, P.G., Eaton, M.A.W., Millican, T.A., Patel, T.P., Bose, C.C., Carey, N.H. and Doel, M.T. Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin. Nucleic Acids Res. 10 (1982) 2177–2187. [DOI] [PMID: 6283469] |
| 3. |
Visser, S., Slangen, C.J. and van Rooijen, P.J. Peptide substrates for chymosin (rennin). Interaction sites in κ-casein-related sequences located outside the (103-108)-hexapeptide region that fits into the enzyme's active-site cleft. Biochem. J. 244 (1987) 553–558. [PMID: 3128264] |
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| [EC 3.4.23.4 created 1961 as EC 3.4.4.3, transferred 1972 to EC 3.4.23.4, modified 1986] |
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