The Enzyme Database

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Accepted name: sortase B
Reaction: The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a NPXTN motif is cleaved between the Thr and Asn residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan.
Other name(s): SrtB
Comments: In peptidase family C60.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS
1.  Zong, Y., Mazmanian, S.K., Schneewind, O. and Narayana, S.V. The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall. Structure 12 (2004) 105–112. [DOI] [PMID: 14725770]
2.  Bierne, H., Garandeau, C., Pucciarelli, M.G., Sabet, C., Newton, S., Garcia-del Portillo, F., Cossart, P. and Charbit, A. Sortase B, a new class of sortase in Listeria monocytogenes. J. Bacteriol. 186 (2004) 1972–1982. [DOI] [PMID: 15028680]
3.  Comfort, D. and Clubb, R.T. A comparative genome analysis identifies distinct sorting pathways in gram-positive bacteria. Infect. Immun. 72 (2004) 2710–2722. [PMID: 15102780]
[EC created 2009]

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