| EC |
3.4.22.52 |
| Accepted name: |
calpain-1 |
| Reaction: |
Broad endopeptidase specificity |
| Other name(s): |
μ-calpain; calcium-activated neutral protease I |
| Comments: |
In peptidase family C2. Requires Ca2+ at micromolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53, calpain-2. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 78990-62-2 |
| References: |
| 1. |
Dutt, P., Spriggs, C.N., Davies, P.L., Jia, Z. and Elce, J.S. Origins of the difference in Ca2+ requirement for activation of μ- and m-calpain. Biochem. J. 367 (2002) 263–269. [DOI] [PMID: 12014988] |
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| [EC 3.4.22.52 created 1981 as EC 3.4.22.17, transferred 2003 to EC 3.4.22.52] |
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