| EC |
3.4.22.39 |
| Accepted name: |
adenain |
| Reaction: |
Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly┼Xaa- and -Yaa-Xaa-Gly-Xaa┼Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid) |
| Comments: |
A cysteine endopeptidase from adenoviruses, the type example of peptidase family C5, with a protein fold unlike that known for any other peptidase [2]. Activity is greatly stimulated by the binding to the enzyme of an 11-residue peptide from the adenovirus capsid protein pre-VI at a site separate from the active site [1] |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 369652-03-9 |
| References: |
| 1. |
Webster, A., Hay, R.T. and Kemp, G. The adenovirus protease is activated by a virus-coded disulphide-linked peptide. Cell 72 (1993) 274–275. [DOI] [PMID: 8422686] |
| 2. |
Ding, J.Z., McGrath, W.J., Sweet, R.M. and Mangel, W.F. Crystal structure of the human adenovirus proteinase with its 11 residue cofactor. EMBO J. 15 (1996) 1778–1783. [PMID: 8617222] |
| 3. |
Weber, J.M. Adenovirus protease. In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Ed.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, pp. 741–743. |
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| [EC 3.4.22.39 created 2000] |
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