The Enzyme Database

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Accepted name: cathepsin S
Reaction: Similar to cathepsin L, but with much less activity on Z-Phe-Arg┼NHMec, and more activity on the Z-Val-Val-Arg┼ compound
Comments: A lysosomal cysteine endopeptidase that is unusual amongst such enzymes for its stability to neutral pH. In peptidase family C1 (papain family)
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 71965-46-3
1.  Turnšek, T., Kregar, I. and Lebez, D. Acid sulphydryl protease from calf lymph nodes. Biochim. Biophys. Acta 403 (1975) 514–520. [DOI] [PMID: 1182153]
2.  Brömme, D., Steinert, A., Friebe, S., Fittkau, S., Wiederanders, B. and Kirschke, H. The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B. Biochem. J. 264 (1989) 475–485. [PMID: 2604727]
3.  Kirschke, H., Wiederanders, B., Brömme, D. and Rinne, A. Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins. Biochem. J. 264 (1989) 467–473. [PMID: 2690828]
[EC created 1992]

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