ExplorEnz: EC 3.4.22.26

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3.4.22.26

Accepted name:

cancer procoagulant

Reaction:

Specific cleavage of Arg┼Ile bond in Factor X to form Factor Xa

Comments:

Apparently produced only by malignant and fetal cells

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 109456-80-6

References:

1.	Falanga, A. and Gordon, S.G. Isolation and characterization of cancer procoagulant: a cysteine proteinase from malignant tissue. Biochemistry 24 (1985) 5558–5567. [PMID: 3935163]
2.	Falanga, A., Shaw, E., Donati, M.B., Consonni, R., Barbui, T. and Gordon, S. Inhibition of cancer procoagulant by peptidyl diazomethyl ketones and peptidyl sulfonium salts. Thromb. Res. 54 (1989) 389–398. [DOI] [PMID: 2772865]

[EC 3.4.22.26 created 1992]