EC |
3.4.22.2 |
Accepted name: |
papain |
Reaction: |
Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1′ |
Other name(s): |
papayotin; summetrin; velardon; papaine; Papaya peptidase I |
Comments: |
Type example of peptidase family C1 from latex of the papaya (Carica papaya) fruit. Inhibited by compound E-64 and proteins of the cystatin family. |
Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9001-73-4 |
References: |
1. |
Kamphuis, I.G., Drenth, J. and Baker, E.N. Thiol proteases. Comparative studies based on the high-resolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and H, and stem bromelain. J. Mol. Biol. 182 (1985) 317–329. [DOI] [PMID: 3889350] |
2. |
Ménard, R. and Storer, A.C. Papain. In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Ed.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, pp. 555–557. |
|
[EC 3.4.22.2 created 1961 as EC 3.4.4.10, transferred 1972 to EC 3.4.22.2, modified 1976, modified 2000] |
|
|
|
|