The Enzyme Database

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EC 3.2.2.16     
Accepted name: methylthioadenosine nucleosidase
Reaction: S-methyl-5′-thioadenosine + H2O = 5-(methylsulfanyl)-D-ribose + adenine
For diagram of the methionine-salvage pathway, click here
Other name(s): 5′-methylthioadenosine nucleosidase; MTA nucleosidase; MeSAdo nucleosidase; methylthioadenosine methylthioribohydrolase; MTN1 (gene name)
Systematic name: S-methyl-5′-thioadenosine adeninehyrolase
Comments: Unlike EC 3.2.2.9, adenosylhomocysteine nucleosidase, this plant enzyme has little or no activity with S-adenosyl-L-homocysteine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 50812-28-7
References:
1.  Guranowski, A.B., Chiang, P.K. and Cantoni, G.L. 5′-Methylthioadenosine nucleosidase. Purification and characterization of the enzyme from Lupinus luteus seeds. Eur. J. Biochem. 114 (1981) 293–299. [DOI] [PMID: 6783408]
2.  Rzewuski, G., Cornell, K.A., Rooney, L., Burstenbinder, K., Wirtz, M., Hell, R. and Sauter, M. OsMTN encodes a 5′-methylthioadenosine nucleosidase that is up-regulated during submergence-induced ethylene synthesis in rice (Oryza sativa L.). J. Exp. Bot. 58 (2007) 1505–1514. [PMID: 17339651]
3.  Siu, K.K., Lee, J.E., Sufrin, J.R., Moffatt, B.A., McMillan, M., Cornell, K.A., Isom, C. and Howell, P.L. Molecular determinants of substrate specificity in plant 5′-methylthioadenosine nucleosidases. J. Mol. Biol. 378 (2008) 112–128. [PMID: 18342331]
4.  Park, E.Y., Choi, W.S., Oh, S.I., Kim, K.N., Shin, J.S. and Song, H.K. Biochemical and structural characterization of 5′-methylthioadenosine nucleosidases from Arabidopsis thaliana. Biochem. Biophys. Res. Commun. 381 (2009) 619–624. [PMID: 19249293]
[EC 3.2.2.16 created 1983, modified 2004]
 
 


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