EC |
3.1.4.41 |
Accepted name: |
sphingomyelin phosphodiesterase D |
Reaction: |
sphingomyelin + H2O = ceramide phosphate + choline |
Other name(s): |
sphingomyelinase D |
Systematic name: |
sphingomyelin ceramide-phosphohydrolase |
Comments: |
Does not act on phosphatidylcholine, but hydrolyses 2-lysophosphatidylcholine to choline and 2-lysophosphatidate. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 54992-31-3 |
References: |
1. |
Carne, H.R. and Onon, E. Action of Corynebacterium ovis exotoxin on endothelial cells of blood vessels. Nature 271 (1978) 246–248. [PMID: 622164] |
2. |
Soucek, A., Michalec, C. and Souckov, A. Identification and characterization of a new enzyme of the group phospholipase D isolated from Corynebacterium ovis. Biochim. Biophys. Acta 227 (1971) 116–128. [DOI] [PMID: 5543581] |
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[EC 3.1.4.41 created 1978] |
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