The Enzyme Database

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Accepted name: hydroxyacylglutathione hydrolase
Reaction: S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate
Other name(s): glyoxalase II; S-2-hydroxylacylglutathione hydrolase; hydroxyacylglutathione hydrolase; acetoacetylglutathione hydrolase
Systematic name: S-(2-hydroxyacyl)glutathione hydrolase
Comments: Also hydrolyses S-acetoacetylglutathione, but more slowly.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9025-90-5
1.  Racker, E. Spectrophotometric measurements of the metabolic formation and degradation of thiol esters and enediol compounds. Biochim. Biophys. Acta 9 (1952) 577–579. [DOI] [PMID: 13032160]
2.  Uotila, L. Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases. Biochemistry 12 (1973) 3938–3943. [PMID: 4200890]
3.  Uotila, L. Purification and characterization of S-2-hydroxyacylglutathione hydrolase (glyoxalase II) from human liver. Biochemistry 12 (1973) 3944–3951. [PMID: 4745654]
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