| EC |
3.1.2.6 |
| Accepted name: |
hydroxyacylglutathione hydrolase |
| Reaction: |
S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate |
| Other name(s): |
glyoxalase II; S-2-hydroxylacylglutathione hydrolase; hydroxyacylglutathione hydrolase; acetoacetylglutathione hydrolase |
| Systematic name: |
S-(2-hydroxyacyl)glutathione hydrolase |
| Comments: |
Also hydrolyses S-acetoacetylglutathione, but more slowly. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9025-90-5 |
| References: |
| 1. |
Racker, E. Spectrophotometric measurements of the metabolic formation and degradation of thiol esters and enediol compounds. Biochim. Biophys. Acta 9 (1952) 577–579. [DOI] [PMID: 13032160] |
| 2. |
Uotila, L. Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases. Biochemistry 12 (1973) 3938–3943. [PMID: 4200890] |
| 3. |
Uotila, L. Purification and characterization of S-2-hydroxyacylglutathione hydrolase (glyoxalase II) from human liver. Biochemistry 12 (1973) 3944–3951. [PMID: 4745654] |
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| [EC 3.1.2.6 created 1961 (EC 3.1.2.8 created 1961, incorporated 1978)] |
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