| EC |
3.1.11.2 |
| Accepted name: |
exodeoxyribonuclease III |
| Reaction: |
Exonucleolytic cleavage in the 3′- to 5′-direction to yield nucleoside 5′-phosphates |
| Other name(s): |
Escherichia coli exonuclease III; E. coli exonuclease III; endoribonuclease III |
| Comments: |
Preference for double-stranded DNA. Has endonucleolytic activity near apurinic sites on DNA. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9037-44-9 |
| References: |
| 1. |
Lindahl, T., Gally, J.A. and Edelman, G.M. Properties of deoxyribonuclease 3 from mammalian tissues. J. Biol. Chem. 244 (1969) 5014–5019. [PMID: 5824576] |
| 2. |
Richardson, C.C. and Kornberg, A. A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. I. Purification of the enzyme and characterization of the phosphatase activity. J. Biol. Chem. 239 (1964) 242–250. [PMID: 14114850] |
| 3. |
Richardson, C.C., Lehman, I.R. and Kornberg, A. A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. II. Characterization of the exonuclease activity. J. Biol. Chem. 239 (1964) 251–258. [PMID: 14114851] |
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| [EC 3.1.11.2 created 1972 as EC 3.1.4.27, transferred 1978 to EC 3.1.11.2] |
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