EC |
3.1.11.1 |
Accepted name: |
exodeoxyribonuclease I |
Reaction: |
Exonucleolytic cleavage in the 3′- to 5′-direction to yield nucleoside 5′-phosphates |
Other name(s): |
Escherichia coli exonuclease I; E. coli exonuclease I; exonuclease I |
Comments: |
Preference for single-stranded DNA. The Escherichia coli enzyme hydrolyses glucosylated DNA. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9037-46-1 |
References: |
1. |
Blakesley, R.W., Dodgson, J.B., Nes, I.F. and Wells, R.D. Duplex regions in single-stranded phiX174 DNA are cleaved by a restriction endonuclease from Haemophilus aegyptius. J. Biol. Chem. 252 (1977) 7300–7306. [PMID: 71298] |
2. |
Kelley, R.B., Atkinson, M.R., Huberman, J.A. and Kornberg, A. Excision of thymine dimers and other mismatched sequences by DNA polymerases of Escherichia coli. Nature 224 (1969) 495–501. |
3. |
Lehman, I.R. and Nussbaum, A.L. The deoxyribonucleases of Escherichia coli. V. On the specificity of exonuclease I (phosphodiesterase). J. Biol. Chem. 239 (1964) 2628–2636. [PMID: 14235546] |
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[EC 3.1.11.1 created 1972 as EC 3.1.4.25, transferred 1978 to EC 3.1.11.1] |
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