| EC |
3.1.1.51 |
| Accepted name: |
phorbol-diester hydrolase |
| Reaction: |
phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate |
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For diagram of reaction, click here |
| Other name(s): |
diacylphorbate 12-hydrolase; diacylphorbate 12-hydrolase; phorbol-12,13-diester 12-ester hydrolase; PDEH |
| Systematic name: |
12,13-diacylphorbate 12-acylhydrolase |
| Comments: |
Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid); this reaction inactivates the tumour promotor 12-O-tetradecanoylphorbol-13-acetate from croton oil. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 81181-74-0 |
| References: |
| 1. |
Shoyab, M., Warren, T.C. and Todaro, G.J. Isolation and characterization of an ester hydrolase active on phorbol diesters from murine liver. J. Biol. Chem. 256 (1981) 12529–12534. [PMID: 6946062] |
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| [EC 3.1.1.51 created 1984] |
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