ExplorEnz: EC 2.8.3.22

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2.8.3.22

Accepted name:

succinyl-CoA—L-malate CoA-transferase

Reaction:

(1) succinyl-CoA + (S)-malate = succinate + (S)-malyl-CoA
(2) succinyl-CoA + (S)-citramalate = succinate + (S)-citramalyl-CoA

For diagram of the 3-hydroxypropanoate cycle, click here

Glossary:

(S)-citramalate = (2S)-2-hydroxy-2-methylbutanedioate
(S)-malate = (2S)-2-hydroxybutanedioate
(S)-malyl-CoA = (3S)-3-carboxy-3-hydroxypropanoyl-CoA

Other name(s):

SmtAB

Systematic name:

succinyl-CoA:(S)-malate CoA-transferase

Comments:

The enzyme, purified from the bacterium Chloroflexus aurantiacus, can also accept itaconate as acceptor, with lower efficiency. It is part of the 3-hydroxypropanoate cycle for carbon assimilation.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Friedmann, S., Steindorf, A., Alber, B.E. and Fuchs, G. Properties of succinyl-coenzyme A:L-malate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus. J. Bacteriol. 188 (2006) 2646–2655. [DOI] [PMID: 16547052]

[EC 2.8.3.22 created 2014]