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Your query returned 1 entry. Printable version
EC | 2.7.8.7 | ||||||||||||
Accepted name: | holo-[acyl-carrier-protein] synthase | ||||||||||||
Reaction: | CoA-[4′-phosphopantetheine] + an apo-[acyl-carrier protein] = adenosine 3′,5′-bisphosphate + an [acyl-carrier protein] | ||||||||||||
Glossary: | apo-[acyl-carrier protein] = a family of proteins or protein domains that contain a conserved serine residue, which are involved in acyl-group transfer. [acyl-carrier protein] = holo-[acyl-carrier protein] = ACP = holo-ACP = the active form of apo-[acyl-carrier protein], in which the hydroxyl group of the conserved serine is substituted by a 4′-phosphopantetheine group, resulting in a sulfydryl group at which the acyl group to be transferred may then be substituted. |
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Other name(s): | acyl carrier protein holoprotein (holo-ACP) synthetase; holo-ACP synthetase; coenzyme A:fatty acid synthetase apoenzyme 4′-phosphopantetheine transferase; holosynthase; acyl carrier protein synthetase; holo-ACP synthase; PPTase; AcpS; ACPS; acyl carrier protein synthase; P-pant transferase; CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase; CoA-[4′-phosphopantetheine]:apo-[acyl-carrier-protein] 4′-pantetheinephosphotransferase | ||||||||||||
Systematic name: | CoA-[4′-phosphopantetheine]:apo-[acyl-carrier protein] 4′-pantetheinephosphotransferase | ||||||||||||
Comments: | Requires Mg2+. All polyketide synthases, fatty-acid synthases and non-ribosomal peptide synthases require post-translational modification of their constituent acyl-carrier-protein (ACP) domains to become catalytically active. The inactive apo-proteins are converted into their active holo-forms by transfer of the 4′-phosphopantetheinyl moiety of CoA to the sidechain hydroxy group of a conserved serine residue in each ACP domain [3]. The enzyme from human can activate both the ACP domain of the human cytosolic multifunctional fatty-acid synthase system (EC 2.3.1.85) and that associated with human mitochondria as well as peptidyl-carrier and acyl-carrier-proteins from prokaryotes [6]. Removal of the 4-phosphopantetheinyl moiety from holo-ACP is carried out by EC 3.1.4.14, [acyl-carrier-protein] phosphodiesterase. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37278-30-1 | ||||||||||||
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