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Your query returned 1 entry. Printable version
EC | 2.7.8.27 | ||||||||||
Accepted name: | sphingomyelin synthase | ||||||||||
Reaction: | a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol | ||||||||||
For diagram of reaction, click here | |||||||||||
Glossary: | sphingomyelin = a ceramide-1-phosphocholine ceramide = an N-acylsphingoid. The fatty acids of naturally occurring ceramides range in chain length from about C16 to about C26 and may contain one or more double bonds and/or hydroxy substituents at C-2 sphingoid = sphinganine, i.e. D-erythro-2-aminooctadecane-1,3-diol, and its homologues and stereoisomers (see also Lip-1.4) |
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Other name(s): | SM synthase; SMS1; SMS2 | ||||||||||
Systematic name: | ceramide:phosphatidylcholine cholinephosphotransferase | ||||||||||
Comments: | The reaction can occur in both directions [3]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [4]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [4]. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [2]. | ||||||||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 58703-97-2 | ||||||||||
References: |
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