| EC |
2.7.8.23 |
| Accepted name: |
carboxyvinyl-carboxyphosphonate phosphorylmutase |
| Reaction: |
1-carboxyvinyl carboxyphosphonate = 3-(hydroxyphosphinoyl)pyruvate + CO2 |
| Systematic name: |
1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating) |
| Comments: |
Catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 122799-57-9 |
| References: |
| 1. |
Pollack, S.J., Freeman, S., Pompliano, D.L., Knowles, J.R. Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus. Eur. J. Biochem. 209 (1992) 735–743. [DOI] [PMID: 1330557] |
| 2. |
Anzai, H., Murakami, T., Imai, S., Satoh, A., Nagaoka, K., Thompson, C.J. Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus. J. Bacteriol. 169 (1987) 3482–3488. [DOI] [PMID: 3611020] |
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| [EC 2.7.8.23 created 1999] |
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