| EC |
2.7.7.99 |
| Accepted name: |
N-acetyl-α-D-muramate 1-phosphate uridylyltransferase |
| Reaction: |
UDP + N-acetyl-α-D-muramate 1-phosphate = UDP-N-acetyl-α-D-muramate + phosphate |
| Glossary: |
N-acetyl-α-D-muramate = 3-O-[(1R)-1-carboxyethyl]-2-acetoxy-2-deoxy-D-glucopyranose |
| Other name(s): |
murU (gene name) |
| Systematic name: |
UDP:N-acetyl-α-D-muramate 1-phosphate uridylyltransferase |
| Comments: |
The enzyme, characterized from Pseudomonas species, participates in a peptidoglycan salvage pathway. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Gisin, J., Schneider, A., Nagele, B., Borisova, M. and Mayer, C. A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. Nat. Chem. Biol. 9 (2013) 491–493. [DOI] [PMID: 23831760] |
| 2. |
Renner-Schneck, M., Hinderberger, I., Gisin, J., Exner, T., Mayer, C. and Stehle, T. Crystal structure of the N-acetylmuramic acid α-1-phosphate (MurNAc-α1-P) uridylyltransferase MurU, a minimal sugar nucleotidyltransferase and potential drug target enzyme in Gram-negative pathogens. J. Biol. Chem. 290 (2015) 10804–10813. [DOI] [PMID: 25767118] |
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| [EC 2.7.7.99 created 2017] |
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