| EC |
2.7.7.78 |
| Accepted name: |
GDP-D-glucose phosphorylase |
| Reaction: |
GDP-α-D-glucose + phosphate = α-D-glucose 1-phosphate + GDP |
| Systematic name: |
GDP:α-D-glucose 1-phosphate guanylyltransferase |
| Comments: |
The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-α-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Adler, L.N., Gomez, T.A., Clarke, S.G. and Linster, C.L. A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. J. Biol. Chem. 286 (2011) 21511–21523. [DOI] [PMID: 21507950] |
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| [EC 2.7.7.78 created 2011] |
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