ExplorEnz: EC 2.7.7.46

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2.7.7.46

Accepted name:

gentamicin 2′′-nucleotidyltransferase

Reaction:

nucleoside triphosphate + gentamicin = diphosphate + 2′′-nucleotidylgentamicin

Other name(s):

gentamicin 2′′-adenylyltransferase; aminoglycoside adenylyltransferase; gentamycin 2′′-nucleotidyltransferase

Systematic name:

NTP:gentamicin 2′′-nucleotidyltransferase

Comments:

ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 62213-33-6

References:

1.	Angelatou, F., Litsas, S.B. and Kontomichalou, P. Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa. J. Antibiot. 35 (1982) 235–244. [PMID: 6281224]
2.	Naganawa, H., Yagisawa, M., Kondo, S., Takeuchi, T. and Umezawa, H. The structure determination of an enzymatic inactivation product of 3′,4′-dideoxykanamycin B. J. Antibiot. 24 (1971) 913–914. [PMID: 4946513]
3.	Yagisawa, M., Naganawa, H., Kondo, S., Hamada, M., Takeuchi, T. and Umezawa, H. Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor. J. Antibiot. 24 (1971) 911–912. [PMID: 4946512]

[EC 2.7.7.46 created 1976]