EC |
2.7.1.74 |
Accepted name: |
deoxycytidine kinase |
Reaction: |
NTP + deoxycytidine = NDP + dCMP |
Other name(s): |
deoxycytidine kinase (phosphorylating); 2′-deoxycytidine kinase; Ara-C kinase; arabinofuranosylcytosine kinase; deoxycytidine-cytidine kinase |
Systematic name: |
NTP:deoxycytidine 5′-phosphotransferase |
Comments: |
Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9039-45-6 |
References: |
1. |
Durham, J.P. and Ives, D.H. Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme. J. Biol. Chem. 245 (1970) 2276–2284. [PMID: 5442271] |
2. |
Ives, D.H. and Durham, J.P. Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme. J. Biol. Chem. 245 (1970) 2285–2294. [PMID: 5462538] |
3. |
Kessel, D. Properties of deoxycytidine kinase partially purified from L1210 cells. J. Biol. Chem. 243 (1968) 4739–4744. [PMID: 5687717] |
4. |
Momparler, R.L. and Fischer, G.A. Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside. J. Biol. Chem. 243 (1968) 4298–4304. [PMID: 5684726] |
|
[EC 2.7.1.74 created 1972] |
|
|
|
|