| EC |
2.7.1.36 |
| Accepted name: |
mevalonate kinase |
| Reaction: |
ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate |
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For diagram of terpenoid biosynthesis, click here |
| Other name(s): |
mevalonate kinase (phosphorylating); mevalonate phosphokinase; mevalonic acid kinase; mevalonic kinase; mevalonate 5-phosphotransferase ; MVA kinase; ATP:mevalonate 5-phosphotransferase |
| Systematic name: |
ATP:(R)-mevalonate 5-phosphotransferase |
| Comments: |
CTP, GTP and UTP can also act as donors. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9026-52-2 |
| References: |
| 1. |
Hellig, H. and Popják, G. Studies on the biosynthesis of cholesterol. XIII. Phosphomevalonic kinase from liver. J. Lipid Res. 2 (1961) 235–243. |
| 2. |
Levy, G.B. and Popják, G. Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver. Biochem. J. 75 (1960) 417–428. [PMID: 14416398] |
| 3. |
Markley, K. and Smallman, E. Mevalonic kinase in rabbit liver. Biochim. Biophys. Acta 47 (1961) 327–335. |
| 4. |
Tchen, T.T. Mevalonic kinase: purification and properties. J. Biol. Chem. 233 (1958) 1100–1103. [PMID: 13598740] |
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| [EC 2.7.1.36 created 1961] |
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