EC |
2.7.1.169 |
Accepted name: |
pantoate kinase |
Reaction: |
ATP + (R)-pantoate = ADP + (R)-4-phosphopantoate |
Other name(s): |
PoK; TK2141 protein |
Systematic name: |
ATP:(R)-pantoate 4-phosphotransferase |
Comments: |
The conversion of (R)-pantoate to (R)-4′-phosphopantothenate is part of the pathway leading to biosynthesis of 4′-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with β-alanine, followed by phosphorylation (EC 6.3.2.1 and EC 2.7.1.33, respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with β-alanine. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
References: |
1. |
Yokooji, Y., Tomita, H., Atomi, H. and Imanaka, T. Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea. J. Biol. Chem. 284 (2009) 28137–28145. [DOI] [PMID: 19666462] |
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[EC 2.7.1.169 created 2011] |
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