ExplorEnz: EC 2.6.1.36

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2.6.1.36

Accepted name:

L-lysine 6-transaminase

Reaction:

L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate

Glossary:

(S)-2-amino-6-oxohexanoate = L-2-aminoadipate 6-semialdehyde = L-allysine
L-1-piperideine 6-carboxylate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate = (S)-1,6-didehydropiperidine-2-carboxylate

Other name(s):

lysine 6-aminotransferase; lysine ε-aminotransferase; lysine ε-transaminase; lysine:2-ketoglutarate 6-aminotransferase; L-lysine-α-ketoglutarate aminotransferase; L-lysine-α-ketoglutarate 6-aminotransferase

Systematic name:

L-lysine:2-oxoglutarate 6-aminotransferase

Comments:

A pyridoxal-phosphate protein. The product (L-allysine) is converted into the intramolecularly dehydrated form, (S)-2,3,4,5-tetrahydropyridine-2-carboxylate.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9054-68-6

References:

1.	Soda, K., Misono, H. and Yamamoto, T. L-Lysine:α-ketoglutarate aminotransferase. I. Identification of a product, δ-1-piperideine-6-carboxylic acid. Biochemistry 7 (1968) 4102–4109. [PMID: 5722275]
2.	Soda, K. and Misono, H. L-Lysine: α-ketoglutarate aminotransferase. II. Purification, crystallization, and properties. Biochemistry 7 (1968) 4110–4119. [PMID: 5722276]

[EC 2.6.1.36 created 1972, modified 2011]