| EC |
2.5.1.117 |
| Accepted name: |
homogentisate solanesyltransferase |
| Reaction: |
all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 |
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For diagram of the homogentisate pathways, click here |
| Glossary: |
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol = 2-methyl-6-solanesylbenzene-1,4-diol = MSBQ |
| Other name(s): |
HST; PDS2 (gene name) |
| Systematic name: |
all-trans-nonaprenyl-diphosphate:homogentisate nonaprenyltransferase |
| Comments: |
Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10 to C20 prenyl diphosphates, producing main products that are not decarboxylated [2]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Sadre, R., Gruber, J. and Frentzen, M. Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis. FEBS Lett. 580 (2006) 5357–5362. [DOI] [PMID: 16989822] |
| 2. |
Sadre, R., Frentzen, M., Saeed, M. and Hawkes, T. Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis. J. Biol. Chem. 285 (2010) 18191–18198. [DOI] [PMID: 20400515] |
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| [EC 2.5.1.117 created 2014] |
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