| EC |
2.4.1.80 |
| Accepted name: |
ceramide glucosyltransferase |
| Reaction: |
UDP-α-D-glucose + an N-acylsphingosine = UDP + a β-D-glucosyl-N-acylsphingosine |
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For diagram of glycolipid biosynthesis, click here |
| Other name(s): |
UDP-glucose:ceramide glucosyltransferase; ceramide:UDP-Glc glucosyltransferase; uridine diphosphoglucose-ceramide glucosyltransferase; ceramide:UDP-glucose glucosyltransferase; glucosylceramide synthase; UDP-glucose:N-acylsphingosine D-glucosyltransferase |
| Systematic name: |
UDP-α-D-glucose:N-acylsphingosine β-D-glucosyltransferase (configuration-inverting) |
| Comments: |
Sphingosine and dihydrosphingosine can also act as acceptors; CDP-glucose can act as donor. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 37237-44-8 |
| References: |
| 1. |
Basu, S., Kaufman, B. and Roseman, S. Enzymatic synthesis of glucocerebroside by a glucosyltransferase from embryonic chicken brain. J. Biol. Chem. 248 (1973) 1388–1394. [PMID: 4631392] |
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| [EC 2.4.1.80 created 1976] |
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