ExplorEnz: EC 2.4.1.328

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2.4.1.328

Accepted name:

erythronolide mycarosyltransferase

Reaction:

dTDP-β-L-mycarose + erythronolide B = dTDP + 3-α-L-mycarosylerythronolide B

For diagram of erythromycin biosynthesis, click here

Glossary:

dTDP-β-L-mycarose = dTDP-2,6-dideoxy-3-C-methyl-β-L-ribo-hexose
L-mycarose = 2,6-dideoxy-3-C-methyl-L-ribo-hexose

Other name(s):

EryBV

Systematic name:

dTDP-β-L-mycarose:erythronolide B L-mycarosyltransferase

Comments:

Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Zhang, C., Fu, Q., Albermann, C., Li, L. and Thorson, J.S. The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification. ChemBioChem 8 (2007) 385–390. [DOI] [PMID: 17262863]

[EC 2.4.1.328 created 2014]