The Enzyme Database

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Accepted name: 2-deoxystreptamine glucosyltransferase
Reaction: UDP-α-D-glucose + 2-deoxystreptamine = UDP + 2′-deamino-2′-hydroxyparomamine
Glossary: 2′-deamino-2′-hydroxyparomamine = 4-O-α-D-glucopyranosyl-2-deoxy-D-streptamine
Other name(s): kanF (gene name)
Systematic name: UDP-α-D-glucose:2-deoxystreptamine 6-α-D-glucosyltransferase
Comments: Involved in the biosynthesis of kanamycin B and kanamycin C. Also catalyses EC, 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase, but activity is only one fifth of that with UDP-α-D-glucose.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Park, J.W., Park, S.R., Nepal, K.K., Han, A.R., Ban, Y.H., Yoo, Y.J., Kim, E.J., Kim, E.M., Kim, D., Sohng, J.K. and Yoon, Y.J. Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. Nat. Chem. Biol. 7 (2011) 843–852. [DOI] [PMID: 21983602]
[EC created 2012]

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