| EC |
2.4.1.217 |
| Accepted name: |
mannosyl-3-phosphoglycerate synthase |
| Reaction: |
GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(α-D-mannosyl)-3-phosphoglycerate |
| Other name(s): |
MPG synthase; GDP-mannose:3-phosphoglycerate 3-α-D-mannosyltransferase |
| Systematic name: |
GDP-mannose:3-phospho-D-glycerate 3-α-D-mannosyltransferase |
| Comments: |
Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 393512-63-5 |
| References: |
| 1. |
Empadinhas, N., Marugg, J.D., Borges, N., Santos, H. and da Costa, M.S. Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key-enzymes. J. Biol. Chem. 276 (2001) 43580–43588. [DOI] [PMID: 11562374] |
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| [EC 2.4.1.217 created 2002] |
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