| EC |
2.3.1.6 |
| Accepted name: |
choline O-acetyltransferase |
| Reaction: |
acetyl-CoA + choline = CoA + O-acetylcholine |
| Other name(s): |
choline acetylase; choline acetyltransferase |
| Systematic name: |
acetyl-CoA:choline O-acetyltransferase |
| Comments: |
Propanoyl-CoA can act, more slowly, in place of acetyl-CoA. |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9012-78-6 |
| References: |
| 1. |
Berman, R., Wilson, I.B. and Nachmansohn, D. Choline acetylase specificity in relation to biological function. Biochim. Biophys. Acta 12 (1953) 315–324. [DOI] [PMID: 13115440] |
| 2. |
Berry, J.F. and Whittaker, V.P. The acyl-group specificity of choline acetylase. Biochem. J. 73 (1959) 447–458. [PMID: 13799882] |
| 3. |
Fritz, I.B. and Schultz, S.K. Carnitine acetyltransferase. II. Inhibition by carnitine analogues and by sulfhydryl reagents. J. Biol. Chem. 240 (1965) 2188–2192. [PMID: 14299645] |
| 4. |
Schuberth, J. Choline acetyltransferase. Purification and effect of salts on the mechanism of the enzyme-catalysed reaction. Biochim. Biophys. Acta 122 (1966) 470–481. |
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| [EC 2.3.1.6 created 1961] |
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