| EC |
2.3.1.59 |
| Accepted name: |
gentamicin 2′-N-acetyltransferase |
| Reaction: |
acetyl-CoA + gentamicin C1a = CoA + N2′-acetylgentamicin C1a |
| Glossary: |
kanamycin |
| Other name(s): |
gentamycin acetyltransferase II; gentamycin 2′-N-acetyltransferase; acetyl-CoA:gentamycin-C1a N2′-acetyltransferase |
| Systematic name: |
acetyl-CoA:gentamicin-C1a N2′-acetyltransferase |
| Comments: |
The antibiotics gentamicin A, sisomicin, tobramycin, paromomycin, neomycin B, kanamycin B and kanamycin C can also act as acceptors. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 50864-40-9 |
| References: |
| 1. |
Benveniste, R. and Davies, J. Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc. Natl. Acad. Sci. USA 70 (1973) 2276–2280. [DOI] [PMID: 4209515] |
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| [EC 2.3.1.59 created 1976] |
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